|
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
Hypomorphic PCNA mutation underlies a human DNA repair disorder.
|
24911150 |
2014 |
|
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Hepatoblastoma
|
0.510 |
AlteredExpression
|
disease |
BEFREE |
To evaluate Bcl-xL, Bax, PCNA, cytokeratin 19 (CK-19), glycogen content and DNA ploidy expression in hepatoblastoma (HB) and their prognostic value.
|
20803149 |
2010 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that mono-allelic loss of pten in the probasin-driven-ErbB-2 model resulted in increased nuclear cyclin D1 and proliferating cell nuclear antigen levels and decreased disease latency compared to either individual genetic model and, unlike the probasin-driven-ErbB-2 mice, progression to adenocarcinoma.
|
19443706 |
2009 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Mean PCNA expression was higher in squamous carcinomas than in adenocarcinomas but there was marked intra-tumour variation in PCNA index in almost all cases.
|
1351473 |
1992 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In order to explore the application value of DCE-MRI in clinical diagnosis and treatment, guide early clinical diagnosis, evaluate prognosis, guide clinical selection of treatment options and improve medical level, the expression of adenocarcinoma, its relationship with clinicopathology, and the significance of co-expression of the proliferating cell nuclear antigen (PCNA), Ki67 protein and cyclooxygenase 2 (COX-2) in breast cancer are analyzed.
|
31289003 |
2019 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The expression of proliferating cell nuclear antigen and p53 protein was analysed by immunocytochemical methods (PC10, CM1 antisera) in 139 patients with T1-2M0 prostatic adenocarcinomas followed-up for > 12 years. p53 protein was expressed in 21 (15%) tumours (15%), the fraction of positive nuclei being very low (mean SE, 1% +/- 0.7%).
|
7913085 |
1994 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy.
|
1351473 |
1992 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin E expression negatively affects lung cancer prognosis.
|
17360482 |
2007 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of TIM-4 promoted lung cancer cell growth and proliferation, and upregulated the expression of PCNA, cyclin A, cyclin B1 and cyclin D1, accompanied by accumulation of lung cancer cells in S phase.
|
26512878 |
2015 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The reverse transcription quantitative polymerase chain reaction analysis revealed that PCNA‑1 was significantly upregulated (up to 5‑fold) in the lung cancer cells (P<0.05), and the overexpression of miR‑204 caused the downregulation of PCNA‑1 in A549 lung cancer cells.
|
30628638 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that YB-1 expression correlates with Topo IIalpha and PCNA expression in lung cancer.
|
11724293 |
2001 |
|
Malignant tumor of colon
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
This effect was accompanied by pro-apoptosis of C086 in colon cancer cells and lower expression of PCNA in C086 treated colon cancer xenografts.
|
21900746 |
2011 |
|
Malignant tumor of colon
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Functional analysis of cellular proliferative activities, by MTT assay, and invasive potential, by Transwell assay, was conducted on SW620 cells expressing low levels of miR‑185. miR‑185 was found to be significantly downregulated in cancer tissues compared with adjacent non‑cancerous tissues, and was negatively correlated with lymph node metastasis of colon cancer (P<0.001). miR‑185 overexpression in vitro impeded cellular proliferation and invasive potential with reduced expression of HIF‑2α, PCNA and MMP‑2 in SW620 cells transfected with an miR‑185 mimic.
|
25216407 |
2014 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
We examined lung tumors 1-7 mm in largest dimension initiated in male Swiss mice by N-nitrosodimethylamine for pathologic type, Ki-ras mutations and levels of total Ki-ras p21, Ki-ras p21 bound to GTP, raf-1, Erk1 and Erk2 and their phosphorylated (activated) forms, and proliferating cell nuclear antigen.
|
10942532 |
2000 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
To better understand the relationship between specific chromosome changes found in human lung tumors and their phenotypic consequences a the tissue level, an in situ hybridization (ISH) procedure of chromosome 17 and immunohistochemistry of proliferating cell nuclear antigen (PCNA) were done.
|
7911024 |
1993 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
We evaluated the proliferative activity in 62 primary lung tumors by determining the cell's percentage of Ki-67 and immunoreactive PCNA (using MIB-1 and PCNA monoclonal antibodies), classifying Ki-67 and PCNA immunoreactivity into three score groups.
|
29940632 |
2018 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
LHGDN |
[18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung.
|
15967114 |
2005 |
|
Psoriasis
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Nobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4<sup>+</sup> T Cells through Mitogen-Activated Protein Kinase Signaling Pathways.
|
30058806 |
2018 |
|
Psoriasis
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Cyclin E expression in psoriasis was stronger in the granular and spinous layer than in the normal epidermis.
|
29115643 |
2018 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The analysis of the effects of NC on apoptosis in HCC tumor xenografts in mice was carried out by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay; the expression of Bcl-2, Bax, cyclin-dependent kinase (CDK)4, cyclin D1, p21 and proliferating cell nuclear antigen (PCNA) was analyzed by immunohistochemistry; and the protein expression of JAK1 and STAT3 was examined by western blot analysis.
|
23613111 |
2013 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, enhanced expression of NPM in HCC correlated with the level of PCNA (R(2)=0.5639) and with the clinical prognostic parameters such as serum alpha fetal protein level, tumour pathological grading, and liver cirrhosis (P<0.05).
|
17245342 |
2007 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
PCNA messenger RNA (mRNA) levels progressively increased from normals to CAH and to cirrhotic patients, and persisted at a high level in the tumorous and in the nontumorous area of HCC subjects, thus showing that the increase of IGF-II transcripts in CAH and cirrhosis is accompanied by an activation of cell mitosis in these samples.
|
8675143 |
1996 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The SUV correlated with GLUT1 and PCNA expression in HCC, but not Meta patients.
|
24297035 |
2014 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our present study confirmed moderate hyperthermia treatment can promote the proliferation, migration and invasion of hepatocellular carcinoma (HCC) cells, which was evidenced by the results that moderate hyperthermia induced up regulation of proliferating cell nuclear antigen (PCNA) and matrix metalloproteinase-2 (MMP-2).
|
29894725 |
2018 |